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This collection covers Melissa Etheridge's 17-year career in 17 dynamic songs, including hits like "Come to My Window," "I Want to Come Over," and "Bring Me Some Water." It also includes four new recordings: her simmering take on Tom Petty's "Refugee"; a reprise of "Piece of My Heart," which wowed the world in her stunning Grammy Awards show performance this past February; an emotional and heartfelt original song called "This Is Not Goodbye"; and the brand-new "I Run for Life," an inspiring anthem for those who, like Etheridge, have had their lives impacted by breast cancer. Regarding its release, Etheridge says, "I always thought that a greatest hits album was something to aspire to. When you got to the point in your career where you could have one, you did something right."

Etheridge has recorded eight albums over the course of her career. She has won the Grammy Award for Best Female Rock Vocal Performance twice: for the song "Ain't It Heavy" in 1992, and "Come to My Window" in 1994. In 1996, she was honored with the prestigious ASCAP Songwriter of the Year award. The Kansas-born singer/songwriter has sold more than 30,000,000 records worldwide.